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In the biomedical field, the demand for the development of broad-spectrum biomaterials able to inhibit bacterial growth is constantly increasing. Chronic infections represent the most serious and devastating complication related to the use of biomaterials. This is particularly relevant in the orthopaedic field, where infections can lead to implant loosening, arthrodesis, amputations and sometimes death. Antibiotics are the conventional approach for implanted-associated infections, but they have the limitation of increasing antibiotic resistance, a critical worldwide healthcare issue. In this context, the development of anti-infective biomaterials and infection-resistant surfaces can be considered the more effective strategy to prevent the implant colonisation and biofilm formation by bacteria, so reducing the occurrence of implant-associated infections. In the last years, inorganic nanostructures have become extremely …
Publication date: 
1 Feb 2023

Giovanna Calabrese, Giovanna De Luca, Domenico Franco, Dario Morganti, Maria Giovanna Rizzo, Anna Bonavita, Giovanni Neri, Enza Fazio, Fortunato Neri, Barbara Fazio, Francesco Crea, Antonio Alessio Leonardi, Maria Josè Lo Faro, Salvatore Guglielmino, Sabrina Conoci

Biblio References: 
Volume: 145 Pages: 213193
Biomaterials Advances