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We demonstrate the realization of the first label-free optical biosensor based on the room temperature luminescence of silicon nanowires (NWs) tested for the selective detection of C-reactive protein in human serum. High aspect ratio Si NW arrays used as sensing interface, are synthesized by a fast, low cost and Si industrially compatible approach. Si NW optical biosensors are fast and offer a broad concentration dynamic range that can be tuned according to different applications. Moreover, the platform is endowed with a high selectivity toward the target analyte and a sensitivity down to the fM limit of detection, opening the route toward noninvasive analysis in biofluids such as saliva.
American Chemical Society
Publication date: 
10 Nov 2017

Alessia Irrera, Antonio Alessio Leonardi, Cinzia Di Franco, Maria Josè Lo Faro, Gerardo Palazzo, Cristiano D’Andrea, Kyriaki Manoli, Giorgia Franzò, Paolo Musumeci, Barbara Fazio, Luisa Torsi, Francesco Priolo

Biblio References: 
Volume: 5 Issue: 2 Pages: 471-479
ACS Photonics