Method: Adherence to MedD was evaluated in a subgroup of 210 participants of DEDiCa Study using the 14-item PREDIMED questionnaire. Health status related to quality of life perceived by the participants at baseline was assessed through three validated European questionnaires: EuroQol EQ-5D-3L, EORTC QLQ-C30 and EORTC QLQ-BR23. Statistical analyses were performed using a bivariate analysis (Pearson correlation) and univariate ANOVA.Result: Significant correlations were observed between adherence to MedD and HRQOL measures: higher physical function (PF2, r= 0,183, p= 0,007), lower pain symptomatic scale (PA, r=− 0, 16; p= 0, 02) and higher EQ5D3L score (r= 0,149, p= 0, 03), which together indicate an improvementin the general state of health. Patients with high adherence to MedD (score> 7) showed a significant improvement in PF2 (p< 0, 05) and a reduction in symptomatic PA scale (p …